RAF/MEK dependence of KRAS-mutant pancreatic ductal adenocarcinomas.
نویسندگان
چکیده
Studies using genetically engineered mouse models indicate that RAF activation is sufficient to induce pancreatic intraepithelial neoplasms, suggesting that mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor-based combination approaches may have clinical use in patients with pancreatic ductal adenocarcinomas.
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ورودعنوان ژورنال:
- Cancer discovery
دوره 2 8 شماره
صفحات -
تاریخ انتشار 2012